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KMID : 0525619980030020140
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1998 Volume.3 No. 2 p.140 ~ p.155
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Preparation of Chitin and Chitosan Oligosaccharides
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전유진/Jeon YJ
김철호/김세권/Kim CH/Kim SK
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Abstract
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Although chitin and chitosan have various bioactivities such as antimicrobial, antitumor by immunostimulating and elicitor acitivity, their effects in vivo were still ambiguous due to low uptake rates into the interior of the body. Therefore, converting chitin and chitosan to their oligosaccharides is necessary for more effect in vivo. There are two hydrolytic methods, acid hydrolysis and enzymatic hydrolysis, to prepare the oligosaccharides from chitin and chitosan. Acid hydrolysis of chitin and chitosan by inorganic acid led to lower oligosaccharides such monomer to pentamer in quantitative yield, but it gives only low yields of hexamer and heptamer. On the other hand, enzymatic hydrolysis of chitin and chitosan by chitinase and chitosanase have a lot of profits, comparing to acid hydrolysis, which are producing of more available oligosaccharides and more convenient preparing way. The present paper will review various useful methods for preparation of chitin and chitosan oligosaccharides among many literatures reported so far, especially focucing enzymatic hydrolysis and properties of the used enzyme, and valuable processing systems for the hydrolytic reaction
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